Neuropathologic Basis for Alzheimer Spectrum Disease

 
   Lead Investigator:    Jacob Kosyakovsky
   Institution      :    University of Virginia School of Medicine
   E-Mail           :    jk6bw@virginia.edu
   Proposal ID      :    1646



   Proposal Description:
   Despite decades of progress, the neuropathological basis of Alzheimer disease  remains disputed, damaging therapeutic development. The amyloid and tau  hypotheses are both inadequate to explain Alzheimer-related pathological  change. We intend to use the rich neuropathological data set  of NACC alongside  datasets from ADNI, ROSMAP, and the Banner cohort  in a penultimate synthesis  of clinicopathological data. Our goal is to use this data to support an  integrative theory of Alzheimer pathogenesis that convincingly captures and  explains the spectrum of clinical disease, hoping to unify Alzheimer research  behind this model.